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IACP Foundation-Funded Study Published in the International Journal of Pharmaceutical Compounding

Thursday, September 24, 2015   (0 Comments)
Posted by: Dagmar Anderson
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Solid State Stability of Extemporaneously Prepared Levothyroxine Aliquots and Capsules

A study funded by the IACP Foundation has been published in the International Journal of Pharmaceutical Compounding (IJPC), Sep/Oct 2015 - Volume 19, Number 5.


Author(s):  Fortner Jeff, Salton Jason, Carlson Christie, Wheeler Rich, Cote Brianna, Rao Deepa

The purpose of this research was to collect, analyze, and compare stability data for levothyroxine (T4) powder in the anhydrous and pentahydrate form when prepared as an aliquot and in capsules. Two different compounding pharmacies, Central Iowa Compounding and Gateway Medical Pharmacy, used different forms of T4 and aliquot formulations, which were studied to determine the beyond-use date at ±5% or ±10% of labeled strength. T4 was extracted from aliquot and capsule formulations and assessed using reverse-phase highperformance liquid chromatography validated to differentiate between the degraded and original forms of T4.

Please click here to read the Abstract published in IJPC.

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